Miotonía y rigidez muscular en NMD

ID de estudio #: NCT04411732

condición: Trastornos Neuromusculares

Estado: Reclutamiento

The primary objective of this study is to assess stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with dystrophic or non-dystrophic myotonia. The secondary objectives are (1) to provide reference values for stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with dystrophic or non-dystrophic myotonia; to provide reference values for stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with non-myotonic neuromuscular disorders, (3) assess correlations between to compare result values for stiffness, muscle tone, relaxation periods and elasticity with clinical muscle function tests, measured by clinical evaluation (MRC-scale) and the 6-minute walk test; (4) assess correlations between subcutaneous fat and muscle thickness and echogenicity, measured by muscle ultrasound and result values for stiffness, muscle tone, relaxation periods and elasticity.

intervención: MyotonPro, Six-minute walk test, Semiquantitative muscle ultrasound, Hand-held Dynamometry of muscle strength

Resultados: https://clinicaltrials.gov/ct2/show/results/NCT04411732

última actualización: Febrero

fecha de inicio: 1 de octubre de 2019

finalización estimada: Marzo 31, 2023

última actualización: Febrero

tamaño / inscripción: 90

resultados primarios:

• MyotonPro device in patients with dystrophic and non-dystrophic myotonia
  The primary objective of this study is the comparison of viscoelastic stiffness of the underlying tissue measured by stiffness (S), elasticity (D) and relaxation (R) between patients with dystrophic and non-dystrophic myotonia.
• 1 día
  

resultados secundarios:

• MyotonPro device - reference values in patients with dystrophic and non-dystrophic myotonia
  1 día
• MyotonPro device - reference values in patients with non-myotonic neuromuscular disorders
  1 día
• MyotonPro device - correlations between stiffness, muscle tone, relaxation periods and elasticity with clinical muscle function tests
  1 día
• MyotonPro device - correlations between stiffness, muscle tone, relaxation periods and elasticity with subcutaneous fat and muscle thickness and echogenicity
  1 día
• MyotonPro device - correlations between stiffness, muscle tone, relaxation periods and elasticity and the 6-minute-walk test
  1 día

criterios de inclusión:

Criterio de exclusión: Criterios:

Severe comorbidities
Patient is participating in another clinical study using investigational treatment
Patient cannot perform required muscle function tests
the patient, in the opinion of the investigator, is unable to adhere to the requirements of the study

patrocinador: Clínica LMU

Contactos: Stephan Wenninger, Dr. Med., +(49)89440057470, stephan.wenninger@med.uni-muenchen.de

investigadores Stephan Wenninger, Dr. Med.,Neurologist

ubicaciones del centro de prueba: Alemania

• Miotonía y rigidez muscular en NMD
  Benedikt Schoser, MD, + 4989440057470, bschoser@med.uni-muenchen.de